|
|
|
|
 |
 |
HOME > Professor > Nano-Therapeutic Research Team |
|
|
| |
|
 |
| Pyung-Cheon Lee, Ph.
D. |
| Major : Biotechnology |
| Phone: +82-31-219-2461,
E-mail: pclee@ajou.ac.kr, Homepage: http://www.ajou.ac.kr/~molbiotech |
|
| 2007~present |
Assistant Professor in Ajou University |
| 2003~2007 |
Research Associate in
University of Minnesota |
| 2001~2003 |
Postdoc in University
of Minnesota |
| 1997~2001 |
Ph D in Korea Advanced
Institute of Science and Technology |
| |
|
| |
|
|
|
|
| Research Overview |
My research
is focusing on development of “Microbial Cell
Factories” through interdisciplinary approach.
Microbial Cell Factories are (1) “Customized cell
factories” for new bioactive chemicals, (2) “Smart
Biosystems” responding digitally to signals, and
(3) “Protein Engineering Platform” for development
of biocatalysts. These versatile Microbial Cell Factories
can be successfully CREATED by rational and systematic
strategies based on Synthetic Biology, Chemical Biology,
Metabolic Engineering, and Omics.
 |
| Research I |
”Customized
cell factories” for new bioactive chemicals consist
of redesign, reconstruction, and system-level optimization
steps along with protein engineering step.
|
| Research II |
”Smart Biosystems”
are composed of development of naturally evolved turn-on/off
biosystems and optimization/fine-tune step. |
| Research III |
”Protein Engineering Platform”
utilizes “core” or “scaffold”
structures of existing biocatalysts to generate novel
biocatalysts with altered activities and properties. |
| |
|
|
Publications
1. Watts KT, Mijts BN, Lee PC, Manning AJ and Schmidt-Dannert
C (2006) Discovery Of A Substrate Selectivity Switch In
Tyrosine Ammonia Lyase, A New Member Of The Aromatic Amino
Acid Lyase Family. Chemistry and Biology,13(12):1317-1326
2. Watts KT, Lee PC and Schmidt-Dannert C (2006) Biosynthesis
of plant-specific stilbene polyketides in metabolically
engineered Escherichia coli. BMC Biotechnology, 6:22.
3. Mitjs BN, Lee PC and Schmidt-Dannert C (2005) Identification
of a carotenoid oxygenase synthesizing novel acyclic carotenoids:
combinatorial biosynthesis and directed evolution. Chemistry
and Biology, 12: 453-460
4. Lee PC, Petri R, Mijts BN, Watts KT and Schmidt-Dannert
C (2005) Directed evolution of Escherichia coli farnesyl
diphosphate synthase (IspA) reveals novel structural determinants
of chain length specificity. Metabolic Engineering, 7:
18-26 |
|
|
|
|
|
|
|
Ki-Dong Park
